After over 30 years of funding, CCRF has just awarded its 84th research grant! Since Children's Cancer Research Fund is not the arm of any one hospital, it is able to fund research on a national level.
Bill Chang, M.D. (Chair)
Doernbecher Children’s Hospital/Oregon Health & Science University
Portland, OR
Terzah Horton, M.D., Ph.D. (Vice Chair)
Texas Children’s Hospital/Baylor College of Medicine
Houston, TX
Yong-Mi Kim, M.D., Ph.D., M.P.H. (Vice Chair)
Children’s Hospital Los Angeles/University of Southern California
Los Angeles, CA
**Biology of Relapsed and Refractory Leukemias – Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Central Biological Repository
Parekh, Chintan, M.D.
Children’s Hospital Los Angeles
Los Angeles, CA
Taraseviciute, Agne, M.D., Ph.D.
Children’s Hospital Los Angeles
Los Angeles, CA
*Clinical course and immune responses in COVID-19 in children and young adults with cancer
Bill Chang, M.D. (Chair)
Doernbecher Children’s Hospital/Oregon Health & Science University
Portland, OR
Terzah Horton, M.D., Ph.D. (Vice Chair)
Texas Children’s Hospital/Baylor College of Medicine
Houston, TX
Yong-Mi Kim, M.D., Ph.D., M.P.H. (Vice Chair)
Children’s Hospital Los Angeles/University of Southern California
Los Angeles, CA
**Biology of Relapsed and Refractory Leukemias – Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Central Biological Repository
Rheingold, Susan R., M.D. (co-chair)
Children's Hospital of Pennsylvania
Philadelphia, PA
Silverman, Lewis B., M.D. (co-chair)
Dana Farber Cancer Institute
Boston, MA
*A Phase 1 Trial of Temsirolimus in Combination with Etoposide and Cyclophosphamide in Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma
Rheingold, Susan R., M.D. (co-chair)
Children's Hospital of Pennsylvania
Philadelphia, PA
Silverman, Lewis B., M.D. (co-chair)
Dana Farber Cancer Institute
Boston, MA
*A Phase 1 Trial of Temsirolimus in Combination with Etoposide and Cyclophosphamide in Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma
Nirali N. Shah, M.D.
Pediatric Oncology Branch, National Cancer Institute
Bethesda, MD
*A Pilot Study of Vincristine Sulfate Liposome Injection (Marqibo®) in Combination with UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults with Relapse of Acute Lymphoblastic Leukemia
Burke, Michael, M.D.
Medical College of Wisconsin
Milwaukee, Wisconsin
*Epigenetic Reprogramming in Relapse AML: A Phase 1 Study of Decitabine and Vorinostat Followed by Fludarabine, Cytarabine and G-CSF (FLAG) in Children and Young Adults with Relapsed/Refractory AML
Burke, Michael, M.D.
Medical College of Wisconsin
Milwaukee, Wisconsin
*Epigenetic Reprogramming in Relapse AML: A Phase 1 Study of Decitabine and Vorinostat Followed by Fludarabine, Cytarabine and G-CSF (FLAG) in Children and Young Adults with Relapsed/Refractory AML
Rheingold, Susan R., M.D. (co-chair)
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
Silverman, Lewis B., M.D. (co-chair)
Dana Farber Cancer Institute
Boston, Massachusetts
*A Phase 1 Trial of Tremsirolimus in Combination with Etoposide and Cyclophosphamide in Children with Relpased Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma
Burke, Michael, M.D.
Medical College of Wisconsin
Milwaukee, Wisconsin
*A Pilot Study of Decitabine and Vorinostat with Chemotherapy for Relapsed ALL
HEDGE, MEENAKSHI, M.D.
Baylor College of Medicine
Texas
*Adoptive immunotherapy co-targeting tumor cells and tumor endothelium in Glioblastoma
PAREKH, CHINTAN, M.D.
Children's Hospital of Los Angeles
Los Angeles
*Micro-RNA-transcription factor networks in T-cell acute lymphoblastic Leukemia
REDELL, MICHELE, M.D., Ph.D.
Texas Children's Cancer and Hematology Centers
Houston, Texas
*Identifying Chemotherapy Resistance Mechanisms in Relapsed Acute Myeloid Leukemia
SEPE, DANA, M.D.
Center for Childhood Cancer Research & Division of Oncology, The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
*Pharmacokinetics in Pediatric Cancer Patients
DRISSI, RACHID, Ph.D.
Cincinnati Childrens Hospital Medical Center
Cincinnati, Ohio
*Biology Studies in the First Phase I Trial of a Telomerase Inhibitor in Children with Refractory of Recurrent Solid Tumors and Lyphomas
BARBIERI, EVELINE, M.D., Ph.D.
Baylor College of Medicine
Houston, Texas
*Sestrins Modulate p53-Dependent Responses to Chemotherapy in Neuroblastoma.
KRIVTSOV, ANDREI, Ph.D.
Childrens Hospital Boston
Boston, Massachusetts
*Preclinical Assessment of Ctnnb1 Suppression for Treatment of MLL-AF9 AML/LSC.
ROY, UPAL BASU, Ph.D., M.P.H.
New York University Medical Center
New York, New York
*Targeting Sox2-positive Stem Cells in Osteosarcoma.
STAKE, NORIKO, M.D.
University of California, Davis
Sacramento, California
*Leukemia-Specific Ligands Against Childhood Acute Lymphoblastic Leukemia.
ARA, TASNIM, M.D., Ph.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Role of IL-6/STAT-3 and AKT signaling in Neuroblastoma Chemoresistance and Tumor progression in Bone Marrow Microenvironment.
RAINUSSO, NINO, M.D.
Baylor College of Medicine
Houston, Texas
*Immunotherapy to Target Cancer Stem Cells in Pediatric Osteosarcoma.
SATWANI, PRAKASH, M.D.
Columbia University
New York, New York
*A Novel Chemotherapy (Romidepsin) and Immunotherapy (Natural Killer Cell) Based Approach in Pediatric Leukemia and Lymphomas: Potential for Targeted Adoptive Cellular Immunotherapy (ACI).
VROOMAN, LYNDA, M.D.
Dana-Farber Cancer Institute
Boston, Massachusetts
*Volumetric Bone Mineral Density Changes During and After Childhood Acute Lymphoblastic Leukemia Therapy.
KESHELAVA, NINO, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Overcoming Neuroblastoma Drug Resistance with Histone Deacetylase Inhibitors and Flavopiridol.
MITTLEMAN, STEPHEN D., M.D., Ph.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Exploring How Obesity and Adipocytes Affect Childhood Cancer.
OKCU, MEHMET F., M.D., Ph.D.
Baylor College of Medicine, Texas Childrens Hospital
Houston, Texas
*Glutathione S-Transferase P1 Variation and Survival in Children with High Risk Neuroblastoma.
SONG, HAE-RI, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Nuclear Factor I A gene, and Astrocytic Lineage Gene, in Glioma Formation.
ASGHARZADEH, SHAHAB, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Genomics of Metastatic Neuroblastomas Lacking MYCN Amplification.
GREGORY, MARK A., Ph.D.
University of Colorado Health Sciences Center
Aurora, Colorado
*Identifying Candidates for Targeted Therapy in Combination with FLT3 Inhibition for the Treatment of Acute Myeloid Leukemia.
WELLS, JAMES, M.D.
Bringham and Women's Hospital, Inc.
Boston, Massachusetts
*EWS-Flil as an Immuno-Therapeutic Target for Ewing's Sarcoma.
ARMSTRONG, MICHAEL B., M.D., PH.D.
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan
*Impact of N-myc on Chemoresistance in Neuroblastoma.
HELLER, KEVIN N., M.D.
The Rockefeller University
New York, New York
*Epstein-Barr Virus Immunity and Lymphoma.
KEATING, AMY K., M.D.
UCHSC at Fitzsimmons, Pediatrics
Aurora, Colorado
*Mer Receptor Tyrosine Kinase as a Biological Marker and Therapeutic Target for Pediatric Leukemia.
RABIN, KAREN, M.D.
Texas Children's Cancer Center
Houston, Texas
*Acute Lymphoblastic Leukemia in Down Syndrome: An Investigation of Molecular Genetics and Host Toxicity.
BARRY, ELLY FALZARANO, M.D.
Dana Farber Cancer Institute
Boston, Massachusetts
*Pharmacogenomics of Doxorubicin-induced Cardiotoxicity.
KEATES-BALEEIRO, JENNIFER, M.D.
Vanderbilt Children's Hospital
Nashville, Tennessee
*Testing Novel Therapeutics in a Mouse Model if Inv (16).
ZACHAROULIS, STERGIOS, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Preclinical Evaluation of VEGFR2/EGFR Inhibition in Combination with MetronomicTemozolomide in a Mouse Model of High Grade Gliomas.
HAINING, W. NICHOLAS, B.M., B.CH.
Dana Farber Cancer Institute
Boston, Massachusetts
*Targeting telomerase as a cancer antigen: a phase 1 pediatric tumor vaccine trial.
KARAJANNIS, MATTHIAS, A., M.D.
Memorial Sloan-Kettering Cancer Center
New York, New York
*Role of pro-angiogenic factors in leukemia-stroma interactions.
ONEL, KENAN, M.D., PH.D.
The University of Chicago
Chicago, Illinois
*The Identification of Novel Biomarkers and Therapeutic Targets in Pediatric ALL by Correlative Analysis of Genome Copy Number Alterations, mRNA Expression, and Clinical Characteristics.
ASGHARZADEH, SHAHAB, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Gene Expression Profiles of Metastic Neuroblastomas without MYCN Amplification Predict Outcome.
ERDREICH-EPSTEIN, ANAT, M.D., PH.D.
Childrens Hospital Los Angeles
Los Angeles, California
*The antiangiogenic effect of alphav-integrin inhibition combined with fenretinide in mouse models of human brain tumors.
REID, GREGOR, M.D., PH.D.
BC Research Institute for Child and Family Health
Vancouver, British Columbia
*Development of immune therapy for ETV6-AML1 positive leukemia using a novel mouse model.
APLENE, RICHARD, M.D.
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
*Genetic Polymnorphisms and Anthracycline Associated Cardiac Toxicity.
BROWN, VALERIE I., M.D., PH.D.
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania
*Evaluation of mTOR Inhibitors and the Role of IL-7 Signaling in Lymphoid Malignancies.
GRAHAM, DOUGLAS K., M.D., PH.D.
University of Colorado Cancer Center
Denver, Colorado
*Evaluation of role of proto-oncogene c-mer in acute lymphocytic leukemia.
PUNAM, MALIK, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*In Vivo Effects of Erythropoietin Receptor Signaling in Pediatric Tumors.
BATRA, SANDEEP, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Activity of fenretinide (4-HPR) and 4-HPR plus safingol in preventing disease progression against pediatric Ewing's Sarcoma (ES) and Primitive neuroectodermal Tumors (PNET) cell lines In Vitro and In Vivo.
MALIK, PUNAM, M.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Role of Erythropoietin and Erythropoietin Receptor in Pediatric Tumors.
ROOD, BRIAN, M.D.
Children's National Medical Center
Washington, D.C.
*Methylation of the O6-methylguanine methyltransferase (MGMT) gene promoter as a prognostic factor in pediatric high grade glioma and medulloblastoma.
WEIGEL, BRENDA, M.D.
University of Minnesota Medical School
Minneapolis, Minnesota
*Combination Immunotherapy and Chemotherapy for Rhabdomyosarcoma.
MAURER, BARRY J., M.D., PH.D.
Childrens Hospital Los Angeles
Los Angeles, California
*Novel Retinoid Combinations with Selective Cytotoxicity for Malignant Cells.
WANG, LISA L., M.D.
Baylor College of Medicine, Texas Children's Cancer Center
Houston, Texas
*Molecular Basis and Clinical Spectrum of Rothmund-Thomson Syndrome.
SAVASAN, SUREYYA, M.D.
Wayne State University
Detroit, Michigan
*In Vitro Drug-Induced Apoptosis as a Measure of Chemo-sensitivity in Childhood T-Cell Acute Lymphoblastic Leukemia.
VAN TORNOUT, JAN M., M.D., M.S.
Childrens Hospital Los Angeles
Los Angeles, California
*Evidence for Gene - Environmental Interaction(s) in the Etiology of Pediatric Brain Cancer.
SWEETSER, DAVID A., M.D., PH.D.
Fred Hutchinson Cancer Research Center
Seattle, Washington
*The Significance of Loss of Heterozygosity in the Patho-genesis and Prognosis of Pediatric de novo AML.
FU, CECILIA, M.D.
USC School of Medicine/Childrens Hospital Los Angeles
Los Angeles, California
*Evaluation of Apoptotic Oncoproteins in Blast Cells from Pediatric Patients with Leukemia at Diagnosis and at Relapse.
KESHELAVA, NINO, M.D.
USC School of Medicine/Childrens Hospital
Los Angeles, California
*Resistance to Alkylating Agents in Neuroblastoma.
MALONEY, KELLY, M.D.
University of Colorado Health Sciences Center
Denver, Colorado
*Retrospective Analysis of Prognostic Import of TEL Rearrangements and Hyperdiploidy on Treatment Outcomes for Children with Standard Risks ALL treated with a Single Delayed Intensification.
SHOHET, JASON, M.D.
University of Texas Southwestern Medical Center
Dallas, Texas
*Analysis of Differentially Expressive Genes in Normal and Neoplastic B-Cells.
ORCHARD, PAUL, M.D.
University of Minnesota
Minneapolis, Minnesota
*Expression of anti-CD 19 scFv/zeta Chimeric Gene in Human NK Cells.
ERDREICH-EPSTEIN, ANAT, M.D., PH.D.
USC School of Medicine/Childrens Hospital Los Angeles
Los Angeles, California
*Integrin Alpha-v Beta-3 in Angiogenic Signaling in Pediatric Neural Tumors.
ERDREICH-EPSTEIN, ANAT, M.D., PH.D.
USC School of Medicine/Childrens Hospital Los Angeles
Los Angeles, California
*Integrin Alpha-v Beta-3 in Angiogenic Signaling in Pediatric Neural Tumors.
TAUB, JEFFREY, M.D.
Children's Hospital of Michigan
Detroit, Michigan
*The Molecular Basis of Cytarabine Sensity of Down Syndrome Children.
WEST, DANIEL C., M.D.
Dana-Farber Cancer Institute/Harvard Medical School
Boston, Massachusetts
*Testing the feasibility of using the PCR Technique to measure the presence of Ewing's Sarcoma or Peripheral Neuraoecto- dermal Tumors.
SCHMIDT, MARY LOU, M.D.
Northwestern University Children's Memorial Hospital
Chicago, Illinois
*The Biologic Effects of Down-regulation of N-myc Oncogene Expression in Human Neuroblastoma. (continued study)
HAMRE, MERLIN R., M.D., M.P.H.
Children's Memorial Institute for Education and Research
Chicago, Illinois
*Mechanisms of Resistance to Nucleoside Analogue Inhibitors of S-Adenosyl-L-Homocysteine hydrolase in Murine and Human Neuroblastoma Tumor Cell Lines: Enzymatic and Genetic Determinants.
WHITLOCK, JAMES, A., M.D.
Vanderbilt University Medical Center
Nashville, Tennessee
*Acquired and Constitutional Alterations of p53 in the Devel- opment and Progression of Childhood Central Nervous System Tumors.
EMANUEL, PETER D., M.D.
University of Alabama at Birmingham
Birmingham, Alabama
*Mechanisms of Response and Effectiveness of 13-Cis Retinoic Acid in the Treatment of Juvenile Chronic Myelogenous Leukemia.
TOMLINSON, GALE E., M.D., PH.D.
University of Texas Southwestern Medical Center
Dallas, Texas
*A Search for predisposition factors in Breats/Sarcoma Cancer Families.
SCHMIDT, MARY LOU, M.D.
Northwestern University Children's Memorial Hospital
Chicago, Illinois
*The Biologic Effects of Down-regulation of N-myc Oncogene Expression in Human Neuroblastoma.
SHANNON, KEVIN, M.D.
University of California, San Francisco
San Francisco, California
*Mutations of the Neurofibromatosis and Ras Genes in Childhood Myeloproliferative Syndromes.
MOULTON, THOMAS, M.D.
Columbia University College of Physicians & Surgeons
New York, New York
*The Role of Classic Multidrug Resistance in Pediatric Solid Tumors.
RAUCK, AMANDA M., M.D.
Children's Hospital
Columbus, Ohio
*Urokinase and It's Receptor in Pediatric Cancers - the Tumor Biology of Wilms' Tumor and Neuroblastoma, Development and Metastasis.
UMIEL, TEHILA, PH.D.
Children's Hospital of Los Angeles
Los Angeles, California
*Isolation, Molecular Characterization and Induction of Differ- entiation of Mixed Lineage (Myeloid/Lymphoid) Precursors from Norman and Leukemic Human Bone Marrow.
SCHMIDT, MARY LOU, M.D.
Northwestern University Children's Memorial Hospital
Chicago, Illinois
*Inhibition of N-myc Gene Expression with Antisense N-myc RNA.
HUANG, CHIEN-SHENG, M.D.
University of California, San Diego
La Jolla, California
*Use of Ch14.18 and GM-CSF Neuroblastoma.
VAN TORNOUT, JAN M.A., M.D.
Children's Hospital of Los Angeles
Los Angeles, California
*The Use of Neural Networking in Pediatric Outcome of Childhood Cancer.
TOMLINSON, GAIL E., M.D., PH.D.
University of Texas Southwestern Medical Center
Dallas, Texas
*Constitutional p53 Mutations in Childhood Patients.
SAYLORS, ROBERT L. III, M.D.
Washington University School of Medicine
St. Louis, Missouri
*C-myc Activation in Medulloblastoma.
SMITH, THOMAS J., M.D.
National Jewish Center for Immunology and Respiratory Medicine
Denver, Colorado
*Vbeta Specificity of T-cell Leukemia and other T-cell Lymphoproliferative Disorders.
VILLABLANCA, JUDITH, M.D.
Children's Hospital of Los Angeles
Los Angeles, California
*Significance of Cellular Proliferation in Neuroblastoma.
WINICK, NAOMI J., M.D.
University of Texas Southwestern Medical Center
Dallas, Texas
*6-Mercaptopurine Metabolism in Children with Acute Lymphoblastic Leukemia.
GREFFE, BRIAN, M.D.
The Children's Hospital
Denver, Colorado
*Effect of L-Asparaginase on the regulatory coagulation proteins and vWF as a mechanism for thrombosis in children with leukemia and lymphoma.